The Registry Guide for Windows®, formerly RegEdit.com, provides an extensive range of registry tweaks, tricks & hacks for optimizing, enhancing and securing the Windows® XP, 2000, NT, 98, 95, Me and Vista operating systems.
Latest Tweaks For Windows
Stop the system automatically rebooting after Windows Updates (Windows XP/Vista) New
Normally Windows Update will automatically reboot the system when you have your system configured to "Automatically download recommended updates for my computer and install them" and one or more of those updates requires a reboot. This settings changes the behavior so when users are logged in the system will not automatically reboot.

Skip the Open With web service prompt (Windows XP) New
Normally when you attempt to open an unknown file type a popup message is shown asking whether you would like to use the online web service to find the appropriate program to open the file. This setting allows you to disable this prompt, causing the Open With dialog to display immediately.

Open Favorites in a new window (All Windows) New
This tweak adds an additional right-click menu item to your Favorites entries which allows you to choose to open the Favorite in a new window.

Changing the Default Location for .OST and .PST Files (All Windows) New
By default, Outlook places each Offline Folders (.ost) file and Personal Folders (.pst) file that it creates in the %userprofile%\Local Settings\Application Data\Microsoft\Outlook folder. This setting allows you to change the default behavior and store the files in any folder.

Use double-pane Explorer when opening network drives (Windows 98/Me/2000/XP) New
By default when opening network drives (UNC) the Explorer window opens with a single-pane which does not show the Folders section on the left-hand side. This tweak changes the default behavior to open network drives with a double-pane view.